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Microbiota is necessary for the development of Immune system

The gut immune system (lymphocytes B and C, macrophages, dendritic cells…) is the largest immune tissue in the body and is the first to have to deal with pathogens and other ingested xenobiotics. A diverse and well-developed microbiota is necessary for the development of an efficient immune reaction avoiding inflammation response. But immune system is also involved in controlling intestinal microbiota