[Music] okay I'm dr. Ellis and I will give a talk on beauty right not as a specialist of butyrate but for its sling with three major functions and the protection systems have the gut the sort of barrier tie Junction the intestinal alkaline phosphatase and the inducible it shock proteins so beauty light has been shown to rain further get barrier function mainly through acting and on tight Junction protein for example cloudiness one two three depends on the type of experiments and models the second point is that Beauty rate is an inducer of an enzyme which is called intestinal alkaline phosphatase it's a very potent anti-inflammatory enzyme this enzyme is able to very simply two different phosphorylate toxic products from bacteria like lipopolysaccharides and just removing one phosphate from one part of the molecule prevents the recognition of this molecule LPS by the so called or toll-like receptor for in the case of virtually and this just stubs the information cascade and the release of pro-inflammatory cytokines and the further very important point of beauty right it's his stimulating stimulating effect on what we call inducible each shot protein so HSPs are two major ones in the goethe hspeed 27 and and hsp70 both of them are induced by butyrate and when we are induced they make the get much more resistant to any kind of stress whatever it stress or different challenge even a novel stress and so in conclusion butyrate as a very direct effect itself not only as as a fuel for the cell but also as a kind of messenger in using other major functions protecting the gut and contributing to get elf thank you [Music]