From butyrate to gut protection systems and inflammation: molecular and functional aspects

Gut Health

From butyrate to gut protection systems and inflammation: molecular and functional aspects

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April 24, 2019 advancia academy, anti-inflammatory, conference, epigenetics, gut barrier, heat shock protein, heat stress, HSP, IAP, immune defenses, inflammation, intestinal alkaline phosphatase, metabolites, microbiota

Speaker: Dr Jean-Paul LALLES, Human Division, INRA Rennes, France

Butyrate stimulates the activity of the important anti-inflammatory alkaline phosphatase: helping to detoxify the bacterial endotoxins among with LPS and flagellin.
Inducible Heat Shock Proteins (HSP27 and HSP70) maybe activated under stressful conditions to protect the gut.
The endogenous bacteria produced butyrate has been shown to stimulates the iHSP helping the gut. Lastly the role of butyrate as histone deacetylase inhibitor demonstrates its potential on epigenetics.

Advancia Academy 2019- Butyrate: from the Nutrient to the Messenger - Presentation