World Poultry Congress 2022

Metabolites produced by the probiotic Bacillus Subtilis DSM 29784 strenghten intestinal barrier, modulate inflammatory response and gut environment

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October 10, 2022
Presented by Vieco Nuria, PhD, R&I at WPC 2022

Three important metabolites produced by the probiotic Alterion have been identified: hypoxanthine, pantothenate and nicotinic acid. Their effects have been demonstrated in vitro using Caco-2 cell cultures. They stimulate cell proliferation and enhance intestinal integrity as measured by the transepithelial resistance (TEER).

They are also able to modify the microbiota profile at ileum and caecum levels, shifting to more butyrate-producing bacteria and increasing the SCFA production.

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