[Music] so we wanted to organize some discussion around sulfur amino acids and how to revise what we know on sulfur amino acid I know that both of you worked racquel directly on the on the molecule and so I came on the interest in fact today in the portion efficient should we remove obviously real removes antibiotic but how we should reformulate and so on so I would like to challenge both of you on the mezzanine or sulfur amino acid beyond the normal rule for growth and production but before I would like to introduce you to dr. Michael Martin Venegas from the University for the Faculty of pharmacy the bar salon and assistant professor and dr. Drakken Bravo well known by everybody still a member of the board of IFTA and a nutritionist and more than a nutritionist because he targeted a lot of topics along his long career and we follow each other for many years and going from the basic of nutrition the enzyme to the alternative to antibiotics reducing medication and so on so I think welcome to both of you just to address a question you first your feeling about the role of miss I mean beyond the role for pure growth as building blocks so maybe raquel to start I think to consider the metabolism of methionine because during the metabolism of methionine some other useful molecules as Tory cysteine glutathione in other compounds are useful not only to gross or not happening to be a structure but also to to improve the very air and to modulate the immune system and under structure of the intestinal barrier so it's important to consider the metabolism of of also this amino acid and that is interesting because at some single new I would say in the role of Miss even if it's which I'll get that for many years now people are still not using these potential benefits what is your feeling on why people are not you know putting more roles or more benefits of sulfur amino acids yeah probably because and the majority of family they're ruling well but until now they have been the help of antimicrobials or other things but as soon as soon as the time in the time is going so fast and in the future the the pool to production should be related much more to the sustainability and the measurement of situations and probably even the the the structure of the farms is going to change in case of the rain hands and so on so the the chickens and the poultry and the layers will be in a difficult situation different situation different situation and that that play a very important role on the consumption of half to dilash amino acids Raquel said amino acids is very important in the structure of the food scene are very crucial very interesting offensive aria is going to play a very important issue it would be considered probably in the future as a good marker parameter like a feed conversion rate of intake so people that they were related to these two that how is the structure or how is the the safety of the dysfunctional area methionine it probably is going to take a very poor and I like let me remember people from the 70s talking about compensatory effect yeah so that would be very important so sometimes the mini analysis is going to play a role of the construction of maybe please a role on the micro biota but finally when everything is covered the animals with better amino acid composition is going to recover more faster and easy so this morning we had a speech on Messiah need benefits and the Coccidioides challenge and we were a bit frustrated to see there is some potential but maybe he did some work to do to demonstrate the benefits they need to work follow-up when we talk about miss I mean we often talk about a different form of Messiah mean and it looks like it's a specificity of Miss I mean to be usable in his different phone can you comment on that the different form of Messiah deen-al-haq cbs19 because you worked on that the past years when I started to work with hydroxy methionine and methionine most of the articles that I read say that they were very different in frequency because most more times most of times the levels of methionine Wars measure and the hydroxy methionine seems to have lower methionine levels in blood or something in some tissues but our research show that not only have to be considered Messiah Nene but also another time with with the other idea all the metabolites that are that are form are the same so if we consider total sulfur amino acids both hydrogen methane and methane in were equal or what are the same were run the same total so it I think that it's important to consider this the the zoom of this do you think that we have still some work to do on the investigation to do you know on better understanding why find some rocks I'm assigning give more cysteine why because it's these things have been observed measure than zone but we are still curious about how to explain them we don't know that the answer yet yeah so I think that it's important to to continue to be very important because if the functional barrier is also playing other friends about the oxidative stress and inflammation so maybe methane in summertime in hot weathers metal in a scalping that could be all soon as a potential role but you know yes really the way how to influence the end-users on that to say okay maybe I can say what we should do as a producing company you know even with the others to really help the people to value better the potentially could have with some phenomenal city first maybe to to fix a protocol for in a protocol for to study stress inflammation stress in intestinal tract about Kathy with the menu can be about a position to differentiate challenge or fetal position and then to make controls with diets with less informatics Pro informational and to introduce amino acids in different forms you know to see if this can overcome the problem sooner or later because about these things before yeah and do you think fines on today because I know that you are working or so on the other form of I would say I believe acid selenium amino acids like say no cysteines I mean I or CMS I mean do you think that could help us to better understand the functioning the metabolic pathway of the different form of mousseline but but in the in that case it's difficult to know because one specific amino acid follows its specific metabolic pathway so it's not you could draw a picture about all the metabolism but you don't know why or how each metabolite will be upregulated or downregulated depending on the on the on the source we still need to investigate and to it resource on the better understanding so convince people that diet is very important not only additives yeah but yeah we don't work in interaction but that should be much more into okay thank you very much enjoy the rest of the controls [Music]